Critical clinical complications of the respiratory system due to secondary bacterial infections (SBIs) could be the reason for the high mortality rate in COVID-19 patients. COVID-19 patients with severe symptoms are usually treated with a combination of virus- and drug-induced immuno-suppression medicines. Considered chiefly are the biological consequences of these various phenomena rather than their mathematical underpinnings.Īs of 29 July 2022, there had been a cumulative 572,239,451 confirmed cases of COVID-19 worldwide, including 6,390,401 fatalities. These include movements other than due to diffusion, various hindrances to diffusive movement, and the influence of assorted heterogeneities. Particularly emphasized here, however, are numerous complications on phage adsorption rates beyond as dictated by the ideals of standard adsorption theory. Understanding what can influence those rates is very relevant to appreciating both phage ecology and the phage therapy of bacterial infections, i.e., where phages are used to augment or replace antibiotics so too adsorption rates are highly important for predicting the potential for phage-mediated biological control of environmental bacteria. This is a key step governing rates of phage-virion adsorption to their bacterial hosts, thereby underlying a large fraction of the potential for a given phage concentration to affect a susceptible bacterial population. Here, I review the basic process of predicting the likelihoods of phage collision with bacteria.
Two such particles are bacteria and their viruses, the latter called bacteriophages or phages. This too is the case for particles diffusing within liquids. For ideal gasses, the likelihood of collision of two molecules is a function of concentrations as well as environmental factors such as temperature.
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